MUMBAI, India, Sept. 22 -- Intellectual Property India has published a patent application (202611093877 A) filed by Mr. Munna Singh; Dr. Sushil Kumar; Mr. Dharmendra Kumar; Mr. Arman Ali; Mr. Mohd Yameen; Mr. Mohd Nazim; Mr. Maroof Ahmad; Mr. Mohammad Kasim; Mr. Sateesh Kumar; and Mr. Pavan Kausiq on August 03, 2026, for Development And Evaluation Of Omeprazole-Loaded Floating Mucoadhesive Microspheres For Prolonged Anti-Ulcer Treatment.
Inventors include Mr. Munna Singh; Dr. Sushil Kumar; Mr. Dharmendra Kumar; Mr. Arman Ali; Mr. Mohd Yameen; Mr. Mohd Nazim; Mr. Maroof Ahmad; Mr. Mohammad Kasim; Mr. Sateesh Kumar; and Mr. Pavan Kausiq.
The application for the patent was published on September 18, 2026, under issue no. 38/2026.
Abstract: ABSTRACT TITLE: DEVELOPMENT AND EVALUATION OF OMEPRAZOLE-LOADED FLOATING MUCOADHESIVE MICROSPHERES FOR PROLONGED ANTI-ULCER TREATMENT The present invention relates to an omeprazole-loaded floating mucoadhesive microsphere formulation for prolonged anti-ulcer treatment, prepared by a hybrid ionotropic gelation and emulsion solvent evaporation process using sodium alginate, chitosan, hydroxypropyl methylcellulose K4M and ethyl cellulose cross-linked with calcium chloride. The optimised microspheres, obtained at a polymer to drug ratio of two-to-one and a calcium chloride concentration of ten percent, exhibit a drug entrapment efficiency of about eighty-nine point five percent, a floating lag time of about forty-nine seconds, a total floating time exceeding twelve hours, in vitro mucoadhesion of about eighty-four point six percent on gastric mucosa, and sustained release over twelve hours following Korsmeyer-Peppas anomalous transport. The multi-particulate system synergistically combines buoyancy and mucoadhesion, provides localised sustained omeprazole delivery, improves therapeutic efficacy in peptic ulcer disease, permits once-daily dosing, and demonstrates excellent stability under accelerated storage conditions.
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