MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202621078923 A) filed by Shaikh Almas Masroor Muhammad Hasham; Kazi Abusufeeyan Ikbal; Dr. Rajesh Bibhishan Nanaware; Ms. Naushin Minaj Deshmukh; Prachi Jitendra Rathod; Rangrez Rehana Khanam Javed Ahmed; Ms. Almas S. Inamdar; and Hemlata Sanjay Kumavat on June 26, 2026, for Development And Evaluation Of Ferric Maltol-Loaded Eudragit S100 Nanoparticles Incorporated Into A Pullulan–hyaluronic Acid Buccal Film For Ph-Responsive Iron Delivery.
Inventors include Shaikh Almas Masroor Muhammad Hasham; Kazi Abusufeeyan Ikbal; Dr. Rajesh Bibhishan Nanaware; Ms. Naushin Minaj Deshmukh; Prachi Jitendra Rathod; Rangrez Rehana Khanam Javed Ahmed; Ms. Almas S. Inamdar; and Hemlata Sanjay Kumavat.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: ABSTRACT Development and Evaluation of Ferric Maltol-Loaded Eudragit S100 Nanoparticles Incorporated into a Pullulan–Hyaluronic Acid Buccal Film for pH- Responsive Iron Delivery The present disclosure relates to a pH responsive dual trigger nanostructured buccal film system for improved systemic iron delivery. The system consists of ferric maltol-loaded Eudragit S100 nanoparticles homogeneously dispersed into a mucoadhesive polymeric matrix of pullulan and hyaluronic acid. The nanoparticles are intended for pH-responsive delivery of ferric maltol while buccal film is exposed to salivary hydration to create a prolonged mucoadhesive interface on buccal mucosa. The formulation further contains a plasticizer, sweetening agents, flavoring agents and pharmaceutically acceptable excipients for improving flexibility and patient acceptability. After administration, the film provides controlled and sustained release of ferric maltol with improved transmucosal absorption, increased iron bioavailability, and reduced gastrointestinal exposure. The disclosed system reduces gastric irritation, decreases the frequency of dosing, and enhances patient compliance as compared with conventional oral iron formulations. The invention also relates to methods of preparation, administration and therapeutic use of the nanoparticle-loaded buccal film for prevention and treatment of iron deficiency and related disorders.
Disclaimer: Curated by HT Syndication.
