MUMBAI, India, July 7 -- Intellectual Property India has published a patent application (202641076644 A) filed by Dr. Sadhu Venkateswara Rao; and Vijaya Institute Of Pharmaceutical Sciences For Women on June 20, 2026, for Design And Characterization Of An Ethosomal Film-Forming Hydrogel Of Sodium Fusidate For Skin Infections.
Inventors include Dr. Sadhu Venkateswara Rao; Mrs. Sk. Shehanaz; Ms. M. Gayathri; Ms. K. Vasanthi; Ms. L. Srujani; Ms. G. Venkata Lekhya Sri; and Ms. B. Swetha.
The application for the patent was published on July 03, 2026, under issue no. 27/2026.
Abstract: ABSTRACT [0020] A novel ethosomal film-forming hydrogel system incorporating sodium fusidate has been developed to overcome the challenges of conventional topical antibiotic therapies for skin and soft tissue infections. This invention proposes an advanced vesicular carrier integrated within a film-forming polymeric matrix that enhances dermal penetration of the drug, prolongs its residence time on the skin, and provides sustained antibacterial action against Gram-positive pathogens such as Staphylococcus aureus. The system utilizes phospholipid-based ethosomes enriched with ethanol and propylene glycol, embedded into a Carbopol- PVA hydrogel base, creating a flexible, transparent film upon application that acts as a drug reservoir while improving patient compliance through reduced dosing frequency. Optimization via a 2³ full factorial design systematically evaluated the effects of phosphatidylcholine concentration, ethanol content, and propylene glycol levels on entrapment efficiency, yielding an optimized ethosomal formulation with approximately 91.36% entrapment. When incorporated into the hydrogel, the resulting product demonstrated superior in-vitro drug release profiles extending up to 12 hours, enhanced zones of inhibition in antibacterial assays, and excellent physicochemical stability. This innovative dual-mechanism approach combining ethosomal permeation enhancement with film-forming retention offers a distinct advancement over traditional creams or gels by achieving deeper skin delivery and controlled release without systemic side effects, making it highly suitable for managing bacterial skin infections and potentially reducing the risk of antimicrobial resistance.
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