MUMBAI, India, June 30 -- Intellectual Property India has published a patent application (202641068963 A) filed by Darshana S; Shrika Da; Vaishnavi Priya K; Yogavarshini S; and Dr. S. Ramya on June 02, 2026, for Comparative Study Of Marine Derived Collagen Biomaterials On Zebrafish Fin Regeneration Using Morphometric And Regenreation Analysis.
Inventors include Darshana S; Shrika Da; Vaishnavi Priya K; Yogavarshini S; and Dr. S. Ramya.
The application for the patent was published on June 26, 2026, under issue no. 26/2026.
Abstract: ABSTRACT: Marine-derived collagen has emerged as a promtsmg natural biomaterial for regenerative medicine due to its excellent biocompatibility, biodegradability, low immunogenicity, and abundance in aquatic resources. The present study focuses on the extraction, purification, and characterization ofbiocollagen materials obtained fi·om the skin nnrl scales oftwo fish species: Pom:fret and Tilapia. The extracted collagen biomaterials are evaluated for their ability to enhance tissue regeneration using Zebrafish caudal fin regeneration as an in-vivo model system. Adult zcbrafish are subjected to standardized caudal fin amputation am] treated with the prepared marine collagen formulations. Regeneration is monitored over a defined experimental period through sequential imaging under controlled conditions. Morphometric analysis is performed to measure regenerated fin length, area, and percentage recovery, while regeneration kinetics analysis is used to determine growth rate and overall healing dynamics. Histological examination is conducted to assess tissue organization and structural restoration in the regenerated fin. Statistical analysis is applied to compare the regenerative performance of collagen derived from the three fish species and to identify the most effective biomaterial. The study aims to determine the regenerative potential offish-derived collagen and to establish a sustainable approach for converting marine waste into high-value biomaterials. The findings arc expected to contribute to the development of ceo-friendly collagen-based materials for wound healing, tissue repair, and biomedical applicationsABSTRACT: Marine-derived collagen has emerged as a promtsmg natural biomaterial for regenerative medicine due to its excellent biocompatibility, biodegradability, low immunogenicity, and abundance in aquatic resources. The present study focuses on the extraction, purification, and characterization ofbiocollagen materials obtained fi·om the skin nnrl scales oftwo fish species: Pom:fret and Tilapia. The extracted collagen biomaterials are evaluated for their ability to enhance tissue regeneration using Zebrafish caudal fin regeneration as an in-vivo model system. Adult zcbrafish are subjected to standardized caudal fin amputation am] treated with the prepared marine collagen formulations. Regeneration is monitored over a defined experimental period through sequential imaging under controlled conditions. Morphometric analysis is performed to measure regenerated fin length, area, and percentage recovery, while regeneration kinetics analysis is used to determine growth rate and overall healing dynamics. Histological examination is conducted to assess tissue organization and structural restoration in the regenerated fin. Statistical analysis is applied to compare the regenerative performance of collagen derived from the three fish species and to identify the most effective biomaterial. The study aims to determine the regenerative potential offish-derived collagen and to establish a sustainable approach for converting marine waste into high-value biomaterials. The findings arc expected to contribute to the development of ceo-friendly collagen-based materials for wound healing, tissue repair, and biomedical applicationsABSTRACT: Marine-derived collagen has emerged as a promtsmg natural biomaterial for regenerative medicine due to its excellent biocompatibility, biodegradability, low immunogenicity, and abundance in aquatic resources. The present study focuses on the extraction, purification, and characterization ofbiocollagen materials obtained fi·om the skin nnrl scales oftwo fish species: Pom:fret and Tilapia. The extracted collagen biomaterials are evaluated for their ability to enhance tissue regeneration using Zebrafish caudal fin regeneration as an in-vivo model system. Adult zcbrafish are subjected to standardized caudal fin amputation am] treated with the prepared marine collagen formulations. Regeneration is monitored over a defined experimental period through sequential imaging under controlled conditions. Morphometric analysis is performed to measure regenerated fin length, area, and percentage recovery, while regeneration kinetics analysis is used to determine growth rate and overall healing dynamics. Histological examination is conducted to assess tissue organization and structural restoration in the regenerated fin. Statistical analysis is applied to compare the regenerative performance of collagen derived from the three fish species and to identify the most effective biomaterial. The study aims to determine the regenerative potential offish-derived collagen and to establish a sustainable approach for converting marine waste into high-value biomaterials. The findings arc expected to contribute to the development of ceo-friendly collagen-based materials for wound healing, tissue repair, and biomedical applications Keywords: Marine-derived collagen; Biocollagcn Pomfret; Tilapia; Zebrafish; Fin regeneration; Morphometric and Regeneration Analysis; Biomatcrials; Marine biotechnology; Tissue engineering; Wound healing.
Disclaimer: Curated by HT Syndication.
