MUMBAI, India, June 26 -- Intellectual Property India has published a patent application (202641068944 A) filed by Pavithra P; Renisha Gnanajesus; Sripriya A; Vishwanathan N; and Dr. S. Ramya on June 02, 2026, for Comparative Evaluation Of Phaeophyceae(brown Algae)and Kappa Phycus(red Algae)mediated Cerium Oxide And Selenium Nanoparticle Incorporated Collagen Hydrogel For Wound Healing.
Inventors include Pavithra P; Renisha Gnanajesus; Sripriya A; Vishwanathan N; and Dr. S. Ramya.
The application for the patent was published on June 19, 2026, under issue no. 25/2026.
Abstract: The present invention relates to the development and comparative evaluation of a bioactive nanocomposite wound healing hydrogel prepared from marine fish collagen extracted from Caranx ignobilis and incorporated with cerium oxide (Ce02) nanoparticles and selenium (Se) nanoparticles synthesized using Phaeophyceae (brown algae) extracts of Sargassum polycystum, Turbinaria conoides and red algae extract of Kappa phycYs. The marine collagen provides a biodegradable, biocompatible, and low-immunogenic scaffold, while the incorporated nanoparticlcs impart strong antioxidant, antimicrobial, and anti-inflammatory properties essential for enhanced wound healing and tissue regeneration. The fabricated hydrogel exhibits excellent water retention capacity, suitable mechanical strength, controlled biodegradability, and sustained bioactive release behavior, making it effective for both acute and chronic wound environments. The fabrication process involves extraction and purification of fish collagen, green synthesis of Ce02 and Se nanoparticles using brown algae extracts, incorporation of nanoparticles into the collagen matrix, and cross-linking to form a stable hydrogel scaffold. The system is evaluated using advanced characterization techniques such as UV-Visible Spectroscopy, FTIR, XRD, SEM, TEM, DLS, and Zeta Potential analysis to confirm nanoparticle formation, morphology, and structural interactions within the hydrogel matrix. Biological performance is assessed through swelling studies, biodegradation analysis, antimicrobial and antibiofilm activity, MTT cytotoxicity assay, scratch wound healing assay, and ROS scavenging evaluation. The results indicate that both nanocomposite hydrogels significantly enhance fibroblast proliferation, cell migration, and wound closure compared to pure collagen hydrogeL Cerium oxide nanoparticleloaded hydrogel exhibits superior antioxidant activity, whereas selenium nanoparticle-loaded hydrogel shows stronger antimicrobial efficacy. The study demonstrates that brown algae mediated cerium oxide and selenium nanoparticle incorporated fish collagen hydrogels are promising smart biomaterials for wound dressing, tissue regeneration, burn treatment, and advanced regenerative medicine applications.
Disclaimer: Curated by HT Syndication.
