MUMBAI, India, June 30 -- Intellectual Property India has published a patent application (202641073088 A) filed by Saveetha Institute Of Medical And Technical Sciences on June 12, 2026, for Chitoseal Bio.
Inventors include Dr Aathira M; Dr. Pradeep Solete; and Dr. Deepak Nallaswamy Veeraiyan.
The application for the patent was published on June 26, 2026, under issue no. 26/2026.
Abstract: ABSTRACT The present invention relates to the field of endodontic biomaterials and describes a novel chitosan nanoparticle-based bioactive root canal sealer developed to improve the long-term success of root canal treatm~nt hy enhancing antimicrobial activity, sealing ability, biocompatibility, and mineralization potential. Conventional endodontic sealers such as zinc oxide eugenol, resin-based sealers, and calcium hydroxide sealers exhibit limitations including microlcukoge, inadequate antimicrobial cfficncy, cytotoxicity, and insufficient bioactivity, which may lead to reinfection and failure of endodontic therapy. Although recently introduced bioceramic sealers show improved biocompatibility and mineralization, they may present disadvantages such as high cost, difficult retrievability, and limited antimicrobial effect. Therefore, rhe development of a new bioactivc scaler with improved biological and physical properties is required. The present invention proposes a powder-liquid bioactive sealer formulation incorporating chitosan nanoparticles as the primary biofunctional component combined with calcium silicate-based bioceramic materials. Chitosan, a natural polysaccharide derived from chitin, possesses antimicrobial, biodegradable, and biocompatible properties, and in nanoparticle form it exhibits enhanced penetration into dentinal tubules, improved interaction with dentin collagen, and increased surface activity. The formulation further includes tricalcium silicate, dicalcmm silicate, calcium phosphat :, .:alcium hydroxide, and zirconium oxide, which collectively contribute to bioactivity, radiopacity, mineralization, and sealing ability. The sealer is designed to be used in powder-liquid form to provide acceptable handling, working time, and setting characteristics suitable for clinical endodontic procedures. The developed material is expected to demonstrate superior antimicrobial activity against endodontic pathogens including Enterococcus faecalis, enhanced dentin wettability, improved sealing with reduced micro leakage, stimulation of hard tissue formation, and low cytotoxicity to periapical tissues. Evaluation of the material includes in-vitro tests such as physicochemical characterization, solubility, setting time, film thickness, cytotoxicity assay, minimal inhibitory concentration, biofilm assay, sealing ability, and push-out bond strength, along with ex-vivo dentin interaction studies and in-vivo animal and clinical trials. The invention provides a novel, cost-effective, bioactive, and antimicrobial endodontic sealer with potential applications in root canal obturation, regenerative endodontics, and advanced dental biomaterials, thereby offering improved clinical outcomes compared with currently available sealers.
Disclaimer: Curated by HT Syndication.
