MUMBAI, India, Sept. 28 -- Intellectual Property India has published a patent application (202541027614 A) filed by Vaidhyanathan Baskaran; Yogavarshini Ravikumar; Soundharya Ramesh; and Shyam Sundhar Saravanan on March 25, 2025, for Biomimetic Scaffolds Comprising Of Quercetin Loaded In Chitosan Polymer Doped With Hydroxyapatite Na.
Inventors include Vaidhyanathan Baskaran; Yogavarshini Ravikumar; Soundharya Ramesh; and Shyam Sundhar Saravanan.
The application for the patent was published on September 25, 2026, under issue no. 39/2026.
Abstract: S.ABSTRACT OF THE INVENTION: Bone tissue engineering offers a promising alternative to conventional grafting techniques for orthopaedic applications. This project focuses on developing biomimetic scaffolds composed of quercetin-loaded chitosan polymer doped with hydroxyapatite (HAP) nanomaterials to enhance bone regeneration. Chitosan provides a biocompatible and biodegradable matrix, HAP mimics. the mineral structure of bone, and quercetin, a natural antioxidant and antiinflammatory agent, promotes osteoblast differentiation and reduces oxidative stress during healing. The scaffold is fabricated using an optimized synthesis process and characterized through Scanning Electron Microscopy (SEM) for surface morphology, Energy Dispersive Xray Analysis (EDAX) for elemental composition, Fourier Transform Infrared Spectroscopy (FTlR) for chemical bonding, and X-Ray Diffraction (XRD) for crystallinity assessment. Further mechanical testing assesses compressive strength and elasticity, essential for loadbearing orthopaedic applications. In vitro biocompatibility studies, including MTT assay for cell viability and Live/Dead staining, determine the scaffold's cytocompatibility and ability to support bone cell proliferation. Controlled drug release studies analyse quercetin's sustained delivery, ensuring long-term therapeutic effects. By combining bioactivity, structural integrity, and controlled drug release, this scaffold presents an efficient, biodegradable, and osteoconductive solution for treating bone defects, fractures, and orthopaedic implant integration, offering significant advancements in regenerative medicine. =
Disclaimer: Curated by HT Syndication.
