MUMBAI, India, Aug. 31 -- Intellectual Property India has published a patent application (202621083342 A) filed by Ansicht Voneden India on July 07, 2026, for Biological Compositions And Scaffolds For In Situ Pancreatic Islet Regeneration.
Inventor includes Dr. Ajinkya Inamdar.
The application for the patent was published on August 28, 2026, under issue no. 35/2026.
Abstract: ABSTRACT BIOLOGICAL COMPOSITIONS AND SCAFFOLDS FOR IN SITU PANCREATIC ISLET REGENERATION The present disclosure provides engineered biological compositions and stackable bio-fabricated scaffolds for in situ pancreatic islet regeneration. A library of twenty engineered pancreatic expression constructs (SEQ ID NOs: 1 to 20), carried on a self-inactivating (SIN), third-generation, integrating lentiviral backbone, is organised into a vascular-priming module, an immunoprotection module, an epigenetic-opener module, and an endocrine-lineage module. The constructs generate engineered cargo-loaded extracellular vesicles presenting secretory ligands, membrane-displayed receptors and checkpoint ligands, and transiently delivered reprogramming factors through a multi-pathway sorting-motif architecture comprising a DLG4 luminal tag, a lactadherin C1C2 membrane anchor, and a Syntenin-1 adapter bearing a THOP1/PREP protease-cleavable linker. A stackable macro-block scaffold (1280) defines a depth-axis layered concentration gradient of vesicle populations with a heparin-functionalised, cell-presence-gated release matrix and an internal receiving cavity (1289) configured to receive a cellular implant plug (1290). The disclosure does not concern any method of treatment of the human or animal body. (
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