MUMBAI, India, July 31 -- Intellectual Property India has published a patent application (202411096065 A) filed by Lovely Professional University on December 05, 2024, for Bioisosteric Analogues For Selective Alpha-Amylase Inhibition In Diabetes Management.
Inventors include Pranshul Awasthi; and Shivani Sharma.
The application for the patent was published on July 24, 2026, under issue no. 30/2026.
Abstract: The present invention relates to the field of medicinal chemistry, specifically to the development of bioisosteric analogues for selective alpha-amylase inhibition, which is crucial in diabetes management. The invention comprises a core structure featuring a bioisosteric analogue of a thiazolidine ring, selected from thiadiazole and oxazole rings, with strategically positioned hydroxyl and carboxyl groups to enhance hydrogen bonding with the active site of alpha-amylase. Additionally, methoxy or ethoxy side chains are attached to the core structure to increase lipophilicity, thereby enhancing binding affinity and reducing degradation in the gastrointestinal tract. The invention also includes methods for preparing these bioisosteric analogues, involving the design of the core structure, incorporation of functional groups through novel catalytic reactions, and evaluation using in vitro enzyme assays and computational docking studies. The selectivity of the inhibitor is ensured by testing against other enzymes, such as alpha-glucosidase, to minimize off-target effects. Dated this …. Day of November, 2024 Dr. Monica Gulati Registrar Lovely Professional University
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