MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202641093775 A) filed by Saveetha Institute Of Medical And Technical Sciences on August 03, 2026, for Bioactive Apigenin-Coated Surgical Sutures For Accelerated Wound Healing And Infection Resistance.
Inventors include Dr Neha S; Dr Arvina Rajasekar; and Dr. Deepak Nallaswamy Veeraiyan.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: Sutures play a critical role in surgical wound management by approximating tissue margins and supporting repair. Conventional suture materials, however, function primarily as passive mechanical aids and may provoke localized inflammation or microbial adherence, potentially delaying healing. Contemporary advancements in biomaterials emphasize biofunctional surface modification to enhance therapeutic outcomes while maintaining mechanical strength. Apigenin, a plant-derived flavonoid abundant in Matricaria chamomilla and Apium graveolens, exhibits well-documented antioxidant, anti-inflammatory, antimicrobial, and tissue-regenerative effects. It modulates cytokine activity, mitigates oxidative stress, suppresses bacterial colonization, and promotes fibroblast proliferation and collagen deposition, collectively contributing to improved wound repair. Integrating such phytochemicals with biomedical substrates represents a promising, biocompatible approach to achieving active healing at surgical sites. The present invention discloses a novel apigenin-coated surgical suture fabricated through a controlled surface-coating process that ensures uniform adherence and sustained release of apigenin. The primary embodiment employs silk sutures, valued for their tensile strength and handling properties, while the coating methodology is adaptable to other polymeric materials such as polyglycolic acid (PGA), polydioxanone (PDO), polycaprolactone (PCL), polypropylene, and polyester. This innovation confers intrinsic therapeutic functionality without altering the suture's structural integrity, yielding a bioactive wound-closure device with enhanced anti-inflammatory, antioxidant, and antimicrobial properties suitable for applications in periodontics, plastic surgery, general surgery, and related medical fields.
Disclaimer: Curated by HT Syndication.
