MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202543003500 A) filed by Transcell Oncologics Private Limited on January 15, 2025, for Artificial Intelligence (ai)-Based Workstation Module For Repeat Dose Toxicity Assessments.
Inventor includes Subhadra Dravida.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: The present invention discloses an artificial intelligence (AI)-based workstation module for repeat dose toxicity assessments. A human MicroPhysiological System (hMPS) simulates microenvironment of the human system to evaluate immune responses to a test substance. Phenotype data are generated from a micrograph by treating hMPS with increasing the test substance concentrations. Micrographs are analyzed and IC50 of the specific test substance is calculated and determined using AI system. The IC50 value from the graphs is compared with that from LDH assay on hMPS treated with increasing the test substance concentrations. A 5% to 20% IC50 dose is administered for 2-4 hours, followed by a two-day recovery, with test substance administration on days 1, 4, and 7. Further, cells are collected on day 10 for downstream analysis. Cytotoxicity percentage is evaluated using AI system and validated by RNA transcriptomics, generating heat maps of toxicity-related genes to provide insights into toxicity pathways. (Ref. FIG. 1)
Disclaimer: Curated by HT Syndication.
