MUMBAI, India, Sept. 14 -- Intellectual Property India has published a patent application (202621104583 A) filed by Dr. Ajit Vishnupant Dale on August 31, 2026, for Apocynin-Amine Hybrid Compounds And Process For Preparation Thereof.
Inventors include Dr. Ajit Vishnupant Dale; Mr. Pratik Vitthal Kodag; Miss Soniya Sudhakar Chavan; Miss Niharika Dhananjay Chougule; Miss Sakshi Hanmant Mane; Miss Rajeshwari Rinesh Kolhapure; Miss Mansi Sandeep Mane; Miss Shreya Deepak Chavan; Miss Trupti Prashant Agalgave; Miss Yogita Rajaram Sutar; and Miss Geetanjali Vijay Nikam.
The application for the patent was published on September 11, 2026, under issue no. 37/2026.
Abstract: The present invention relates to novel apocynin-amine hybrid compounds of Formula (I), or pharmaceutically acceptable salts, solvates, hydrates, stereoisomers, tautomers, or prodrugs thereof, useful as acetylcholinesterase inhibitors. The invention further provides a process for preparation of the compounds comprising nucleophilic ring opening of an oxirane-substituted apocynin intermediate with selected secondary amines. The compounds comprise apocynin derivatives bearing pyrrolidine, piperidine, piperazine, benzylpiperidine, benzylpiperazine and related amino moieties. The disclosed compounds were evaluated for acetylcholinesterase inhibitory activity and subjected to molecular docking, density functional theory and molecular dynamics studies. Representative compounds ACT-1BP, ACT-4BP and ACT-NBA exhibited promising acetylcholinesterase inhibitory activity, supporting their potential utility as acetylcholinesterase inhibitor candidates. FIG. 1
Disclaimer: Curated by HT Syndication.
