MUMBAI, India, Sept. 28 -- Intellectual Property India has published a patent application (202641113886 A) filed by Anurag University on September 23, 2026, for An Intranasal Ramelteon Drug Delivery System For Insomnia.
Inventors include Dr. Padmanabha Rao Amarachinta; Dr. Vasudha Bakshi; and Ms. Vemuri Manoja.
The application for the patent was published on September 25, 2026, under issue no. 39/2026.
Abstract: ABSTRACT The present invention provides an intranasal Ramelteon drug delivery system (100) comprising a Ramelteon-loaded nanostructured lipid carrier (101), glyceryl monostearate as a solid lipid (102), oleic acid as a liquid lipid (103), Tween 80 as a surfactant (104), Poloxamer 407 as a stabilizer (105), an aqueous phase (106), an optimized NLC dispersion (107), and a Carbopol 934 mucoadhesive gel base (108). Ramelteon, the lipids and ethanol:acetone (1:1) are processed by solvent evaporation, stirring, probe sonication and cooling. A three-factor, three-level Box–Behnken design optimizes lipid concentration, surfactant concentration and sonication time. The optimized formulation provides 82.35% entrapment efficiency, 95.48 nm particle size and 92.37% cumulative release. The optimized NLC dispersion is incorporated into the Carbopol 934 gel base for intranasal delivery with modified release and nasal permeation characteristics. The figure associated with abstract is Fig. 1.
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