MUMBAI, India, Nov. 2 -- Intellectual Property India has published a patent application (202521039241 A) filed by Precise Biopharma Pvt Ltd on April 23, 2025, for An Improved Process For The Preparation Of Form-I Of Polmacoxib.
Inventors include Dnyanadeo Jotiba Kesarkar; Sunil Sadanand Sukthankar; and Roshan Moreshwar Belose.
The application for the patent was published on October 30, 2026, under issue no. 44/2026.
Abstract: The present invention relates to a novel process for the preparation of Form-I of Polmacoxib with high purity and improved yield. The process involves a controlled crystallization technique that ensures the formation of a stable polymorphic form, minimizing impurities and enhancing batch-to-batch reproducibility. The method utilizes optimized solvent systems, precise temperature control, and specific seeding techniques to selectively obtain Form-I while avoiding undesired polymorphic transformations. The resulting Polmacoxib Form-I exhibits superior physicochemical properties, including enhanced solubility, stability, and bioavailability, making it suitable for pharmaceutical applications. The invention provides an efficient, scalable, and cost-effective manufacturing process, ensuring compliance with regulatory standards. This invention addresses key challenges in the commercial production of Polmacoxib, ensuring pharmaceutical efficacy and formulation stability.
Disclaimer: Curated by HT Syndication.
