MUMBAI, India, July 7 -- Intellectual Property India has published a patent application (202621056939 A) filed by Siipl-Ip Cell Serum Institute Of India Private on May 05, 2026, for An Improved Process For Preparing And Purifying Polysaccharide Protein Conjugate.
Inventors include Pisal Sambhaji Shankar; Avalaskar Nikhil Dattatray; Chavan Vishal Bharat; Kamat Chandrashekhar Dwarkanath; Kamble Swapnil Ashok; and Nazirkar Devidas Kantilal.
The application for the patent was published on July 03, 2026, under issue no. 27/2026.
Abstract: The present invention relates to an improved process for preparing and purifying N.meningitidis serogroup C polysaccharide-CRM197 protein conjugate with high conjugation efficiency and improved recovery, wherein the process uses optimized ratio of polysaccharide to CPPT to protein and optimized concentration of polysaccharide during conjugation. The conjugate obtained is further purified by concentration, diafiltering and maintaining a low transmembrane pressure (TMP) and applying back pressure. The method produces a conjugate with low free polysaccharide content.
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