MUMBAI, India, Sept. 22 -- Intellectual Property India has published a patent application (202641110841 A) filed by Dr. Latha Kukati; Javeria Tamkeen; Aisha Rahman; Pokalkar Ushake Monica; Kasala Vaishnavi; and G. Pulla Reddy College Of Pharmacy on September 16, 2026, for Ambrisentan Solubility Enhancement Using Liquisolid Method And Optimization With 32 Full Factorial Design.
Inventors include Dr. Latha Kukati; and Javeria Tamkeen.
The application for the patent was published on September 18, 2026, under issue no. 38/2026.
Abstract: ABSTRACT The present invention relates to a liquisolid compact system (100) and a method for enhancing the aqueous solubility and dissolution rate of ambrisentan, a poorly water-soluble BCS Class II drug. The system comprises ambrisentan dissolved in a non-volatile solvent to form a drug solution, admixed with a carrier material and a coating material to form a liquid-powder admixture, and further blended with a binder, glidant, and lubricant before compression into a compact. The amount of the non-volatile solvent and the carrier-to-coating ratio are optimized using a two-factor, three-level (3²) full factorial experimental design based on percentage drug release, angle of repose, and disintegration time as response variables. The optimized compact exhibits about a four-fold increase in aqueous solubility, an amorphous form of the drug, enhanced dissolution, and acceptable physicochemical stability under accelerated storage conditions. The figure associated with the abstract is Fig. 1.
Disclaimer: Curated by HT Syndication.
