MUMBAI, India, Sept. 22 -- Intellectual Property India has published a patent application (202641109547 A) filed by Dumala Naresh; Risy Namratha Jamullamudi; and Koneru Lakshmaiah Education Foundation Klef on September 11, 2026, for A Validated Liquid Chromatographic Method For Simultaneous Determination Of Treosulfan And Its Related Impurities.
Inventors include Ketineni Gayathri Devi; Risy Namratha Jamullamudi; Divya Narla; Bathula Venkata Narasimha Rao; Anumula Udaya Krishnaveni; Thanniru Durga Bhavani; and Dumala Naresh.
The application for the patent was published on September 18, 2026, under issue no. 38/2026.
Abstract: The present disclosure relates to a validated reverse-phase liquid chromatographic method for the determination of Treosulfan and its related impurities, and a process for development thereof. The method comprises chromatographic separation of Treosulfan using an optimized mobile phase and stationary phase combination, established through systematic design-based optimization of critical method parameters. The process further comprises subjecting Treosulfan to forced degradation under acidic, alkaline, oxidative, reductive, thermal, photolytic, and neutral conditions, followed by identification and structural characterization of the resulting degradation products using mass spectrometric techniques. The disclosed method exhibits stability-indicating capability, adequate resolution of Treosulfan from its degradation products and related impurities, and reproducibility suitable for regulatory validation. The invention further provides a computational toxicity assessment of the identified degradation products, offering utility for quality control, stability testing, and impurity profiling of Treosulfan formulations.
Disclaimer: Curated by HT Syndication.
