MUMBAI, India, Oct. 26 -- Intellectual Property India has published a patent application (202621055511 A) filed by Mrs. Udugade Swati Babaso; and Dr. Sujata A. Jadhav on April 30, 2026, for A Topical Emulgel Composition Combining Hydroalcoholic Extracts Of Coccinia Grandis And Curcuma Longa, And A Process For The Preparation Thereof.
Inventors include Mrs. Udugade Swati Babaso; Dr. Sujata A. Jadhav; Dr. Vishwajeet S. Ghorpade; and Dr. Babaso V. Udugade.
The application for the patent was published on October 23, 2026, under issue no. 43/2026.
Abstract: TOPICAL EMULGEL COMPOSITION COMBINING HYDROALCOHOLIC EXTRACTS OF COCCINIA GRANDIS AND CURCUMA LONGA, AND A PROCESS FOR THE PREPARATION THEREOF Disclosed is a topical emulgel composition comprising hydroalcoholic extracts of Coccinia grandis (leaves and fruits) and of Curcuma longa (rhizomes) in combination with Carbopol 934 as gelling agent, light liquid paraffin as oil phase, Tween 80 and Span 20 as surfactants, propylene glycol, glycerin, triethanolamine and methylparaben, the formulation being optimised by a three-factor, three-level Box-Behnken Design of Experiments targeting viscosity, spreadability, in-vitro drug release, globule size and bioadhesive strength. A process for preparing the composition is also disclosed, comprising formation of a Carbopol 934 gel base, formation of an oil-in-water emulsion incorporating the dissolved extracts, and combination of the gel base and the emulsion in a 1:1 ratio. The optimised combination emulgel exhibits a viscosity of about 21,920 cP, spreadability of about 14.58 seconds, drug release of about 69.92% at 6 hours, globule size of about 216.80 nm, and bioadhesive strength of about 21.45 g. In the carrageenan-induced paw oedema model, the composition produces about 44.4% inhibition of oedema at 5 hours, comparable to marketed diclofenac gel, while in the acetic acid-induced oral ulcer model it produces about 96% ulcer healing by Day 12, exceeding marketed Orasep® gel and the corresponding individual-plant emulgels, thereby establishing a synergistic, Design of Experiments-validated herbal topical therapy for inflammatory and ulcerative conditions of skin and mucosal tissue.
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