MUMBAI, India, Sept. 22 -- Intellectual Property India has published a patent application (202611089284 A) filed by Graphic Era Deemed To Be University on July 22, 2026, for A System And Method For Identification Of Maleic Acid Anhydride Derivatives As Androgen Receptor Inhibitors For Prostate Cancer Treatment.
Inventors include Neha Thakur; Pallavi Singh; Bindu Naik; and Shiva Prasad Kollur.
The application for the patent was published on September 18, 2026, under issue no. 38/2026.
Abstract: The invention relates to computational drug discovery and cancer therapeutics, and more particularly to a system and method for identifying maleic acid anhydride derivatives as androgen receptor inhibitor candidates for prostate cancer treatment. A three-dimensional structure of an androgen receptor ligand-binding domain, including wild-type and/or mutant forms, is prepared and used to define a docking grid for computer-aided docking of a candidate library enriched in maleic acid anhydride derivatives including compounds A, B, and C and analogues thereof. Ranked candidates are filtered using predicted binding energies, docking scores, interaction profiles with key androgen receptor residues, and ADMET and drug-likeness characteristics, followed by biological evaluation in PC-3, DU145, and HEK- 293 cells using MTT and LDH release assays. Computational and biological outputs, including IC50 values, cytotoxicity profiles, and a selectivity index, are integrated, optionally as a composite score, to identify active and selective androgen receptor inhibitor candidates.
Disclaimer: Curated by HT Syndication.
