MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202421086048 A) filed by Tata Memorial Centre-Advanced Centre For Treatment, Research And on November 08, 2024, for A System And A Method For Understanding Effect Of Pharmacological Inhibitors On Cancer Stem Cells (cscs).
Inventors include Dr. Sanjeev Waghmare; Priyanka Joshi; Dr. Pankaj Chaturvedi; and Sonal Negi.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: ABSTRACT A method, a composition, a system, and a kit for cancer stem cells (CSCs) enrichment for inhibitor screening and resistance therapy The present disclosure relates to a method, a composition, a system, and a kit for cancer stem cells (CSCs) enrichment for inhibitor screening and resistance therapy. Particularly, the method involves co-culturing the patient-derived OTSCC cell lines with patient-derived cancer-associated fibroblast (CAFs) cells from the same patient grown in a CAF-conditioned medium. The system and kit relate to investigation of the effect of pharmacological inhibitors on CSCs involved in tumor progression resistant to the therapy. The invention provides a CSC enriched stable cell model, obtained from the co-culturing stem cell and the cancer-associated fibroblasts (CAFs) to screen pharmacological inhibitors. The application is the screening the inhibitory potential of pharmacological inhibitors against CSCs in native environment in presence of CAFs.
Disclaimer: Curated by HT Syndication.
