MUMBAI, India, June 30 -- Intellectual Property India has published a patent application (202621066604 A) filed by Parul University Parul Institute Of Ayurved And Research; Dr. Bhagwan G Kulkarni; Dr. Prasenjit K More; Dr. Kirtan Dave; and Dr. Suwarna A. Meshram on May 27, 2026, for A Synergistic Phytometabolite Composition Derived From Baliospermum Montanum Willd. For Gastrointestinal Secretion And Motility Regulation.
Inventors include Dr. Bhagwan G Kulkarni; Dr. Prasenjit K More; Dr. Kirtan Dave; and Dr. Suwarna A. Meshram.
The application for the patent was published on June 26, 2026, under issue no. 26/2026.
Abstract: The invention relates to phytochemistry and gastrointestinal pharmacology. Existing gastrointestinal regulatory agents operate through single-target mechanisms without integrated regulation of secretion, motility, and neurohumoral pathways. The invention provides a synergistic phytometabolite composition from Baliospermum montanum roots comprising Ursolic acid, Cucurbitacin C, Ganoderic acid F, 24-Hydroxyglycyrrhetic acid, HODE derivatives, HOTE derivatives, and other metabolites identified by LC-MS/MS metabolomic profiling. The composition modulates CFTR-associated secretory pathways, serotonin receptor-mediated motility pathways, and dopamine receptor-associated neurohumoral signaling pathways simultaneously. Molecular docking demonstrates strong binding affinity (docking scores -9.2 to -11.3 kcal/mol) to target proteins 8UBR, 7E2X, and 6VMS. Molecular dynamics simulation confirms conformational stability of the Cucurbitacin C-6VMS complex. In vivo evaluation demonstrates dose-dependent purgative activity with increased stool frequency, altered fecal consistency, and enhanced gastrointestinal secretion. The composition finds use in bowel evacuation, gastrointestinal regulation, and purgative therapy.
Disclaimer: Curated by HT Syndication.
