MUMBAI, India, Aug. 10 -- Intellectual Property India has published a patent application (202621070803 A) filed by Sonopant Dandekar Shikshan Mandalis Sonopant Dandekar Arts,v S Apte Commerce And M H Mehta Science College Palghar on June 06, 2026, for A Novel Process For The Preparation Of 3-((1h-Benzo[d]imidazol-1-Yl)methyl)-5-Amino-1,3,4-Thiadiazole-2(3h)-Thione.
Inventors include Shraddha Shankar Parab; Dr. Suhas Janwadkar; Dr. Dilip Yadav; Dr. Willy Shah; Pooja Shinde; Sunil Gadakh; and Hardik Deshmukh.
The application for the patent was published on July 31, 2026, under issue no. 31/2026.
Abstract: ABSTRACT A Novel Process for the Preparation of 3-((1H-Benzo[d]imidazol-1-yl)methyl)-5-amino-1,3,4-thiadiazole-2(3H)-thione The present invention relates to a novel and efficient process for the preparation of 3-((1H-benzo[d]imidazol-1-yl)methyl)-5-amino-1,3,4-thiadiazole-2(3H)-thione. The process comprises hydroxymethylation of benzimidazole using formaldehyde to obtain 1-(hydroxymethyl)benzimidazole, followed by chlorination to produce 1- (chloromethyl)benzimidazole. In a parallel sequence, 5-amino-1,3,4-thiadiazole-2(3H)-thione is protected using di-tert-butyl dicarbonate to form a Boc-protected intermediate. The protected thiadiazole is subjected to N-alkylation with 1-(chloromethyl)benzimidazole in the presence of a base to yield a coupled intermediate, which is subsequently deprotected under acidic conditions to afford the target compound. The process provides improved yields, operational simplicity, and suitability for industrial scale-up.
Disclaimer: Curated by HT Syndication.
