MUMBAI, India, July 13 -- Intellectual Property India has published a patent application (202441096711 A) filed by Manipal Academy Of Higher Education on June 06, 2025, for A Multi-Pathway Biomarker System And Method For Early Detection Of Renal Decline In Diabetic Patients.
Inventors include Mohan V. Bhojaraja; Priya Rani; Shankar Prasad Nagaraju; Sahana Shetty; Dharshan Rangaswamy; Ravindra Prabhu Attur; Indu Ramachandra Rao; and Srinivas V. Shenoy.
The application for the patent was published on July 10, 2026, under issue no. 28/2026.
Abstract: The present invention discloses a multi-unit assessment system for detecting rapid decline in renal function associated with diabetic kidney disease, particularly without albuminuria. The system comprises a plurality of detection units configured to simultaneously quantify seven biomarkers across glomerular structural, tubular structural, inflammatory, and fibrotic pathways, a sample processing unit, a measurement unit, and an analysis unit. The method includes collecting urine samples, processing through centrifugation to obtain cell-free supernatant, implementing marker-specific dilution ratios of 1:50, 1:100, and 1:2 to obtain biomarker-rich supernatant, and contacting with detection units comprising capture antibodies specific to Cystatin C, KIM-1, NGAL, TNF-a, MCP-1, TGF-ß, and CTGF. The measurement unit quantifies optical density at 450 nanometers through 4-parameter logistic regression. The analysis unit integrates multi-pathway data achieving area under curve exceeding 0.70 and specificity exceeding 85 percent, thereby enabling identification of declining renal function independent of albuminuria status. FIG.1
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