MUMBAI, India, July 24 -- Intellectual Property India has published a patent application (202621067534 A) filed by Sardar Vallabhbhai National Institute Of Technology, Surat on May 29, 2026, for A Microwave-Assisted Metal-Free Process For Direct N-Acylation Of Sulfonamides Using Carboxylic Acids.
Inventors include Shivam Rajesh Vispute; Arpan Jagdishkumar Patel; and Togati Naveen.
The application for the patent was published on July 17, 2026, under issue no. 29/2026.
Abstract: The present invention relates to the field of organic synthetic chemistry and provides a microwave-assisted, metal-free process for preparing an N-acyl sulfonamide product by directly reacting a carboxylic acid substrate with a sulfonamide substrate in a sealed microwave-compatible reaction vessel containing triethyl phosphite, iodine, potassium carbonate, and acetonitrile. Under air atmosphere and microwave irradiation, preferably about 400 W at about 80°C for about 20 minutes, potassium carbonate generates a carboxylate species, while triethyl phosphite and iodine form in situ an electrophilic phosphorus-containing activating species, including an iodophosphonium species, which converts the carboxylate into an activated acyl phosphorus intermediate. The sulfonamide substrate then undergoes nucleophilic acyl substitution to furnish the N-acyl sulfonamide product without pre-forming acid chlorides, anhydrides, esters, azides, transition-metal catalysts, external oxidants, or inert atmosphere.
Disclaimer: Curated by HT Syndication.
