MUMBAI, India, Aug. 31 -- Intellectual Property India has published a patent application (202621010395 A) filed by P. R. Pote Patil College Of Pharmacy, Amravati; Welankiwar, Abhijeet Sanjay; and Ruikar, Dipti Bipinchandra on February 01, 2026, for A Method For Preparing Lipid-Based Microemulsion Cream Formulation.
Inventors include Welankiwar, Abhijeet Sanjay; Ruikar, Dipti Bipinchandra; Bhoyar, Bhushan Santoshrao; and Dighade, Manjiri.
The application for the patent was published on August 28, 2026, under issue no. 35/2026.
Abstract: The present invention is related to a method for preparing lipid-based microemulsion cream formulation. evaluation, and optimization of a lipid-based microemulsion cream incorporating clotrimazole and neem (Azadirachta indica) extract for enhanced antifungal and antimicrobial effects. Clotrimazole, being hydrophobic, demonstrates poor aqueous solubility and limited skin penetration in conventional formulations. In this invention, clotrimazole is incorporated into a lipid-based microemulsion system to improve solubility, bioavailability, and retention. Neem extract is added to provide synergistic antimicrobial, antioxidant, and anti- inflammatory properties. The formulation process involves preparation of aqueous and lipid phases, followed by controlled mixing and stabilization to yield a uniform microemulsion cream. The developed cream exhibits nanometric particle size, desirable zeta potential, and optimal pH, ensuring long-term stability and enhanced skin permeation. In-vitro studies confirmed superior antifungal and antibacterial activity against Candida albicans, Aspergillus niger, Staphylococcus aureus, and Escherichia coli.
Disclaimer: Curated by HT Syndication.
