MUMBAI, India, July 30 -- Intellectual Property India has published a patent application (202641089009 A) filed by Vellore Institute Of Technology on July 21, 2026, for A Method For Preparing Dual-Metal Functionalized Three-Dimensional Chitosan-Based Scaffolds.
Inventors include Debasish Mishra; and Pavan Gutti.
The application for the patent was published on July 24, 2026, under issue no. 30/2026.
Abstract: The present disclosure proposes a method for preparing dual-metal functionalized three-dimensional chitosan-based scaffolds incorporating ionic crosslinking and coordinated metal-ion functionalization to provide porous biodegradable scaffold architectures suitable for tissue engineering and biomedical applications. The method comprises preparing a homogeneous chitosan solution in an aqueous acetic acid solution, casting the solution into a mould, freezing and lyophilizing the cast solution to obtain a porous three-dimensional chitosan scaffold (208), ionically crosslinking the scaffold using a sodium tripolyphosphate solution, preparing a dual-metal ion solution comprising zinc ions together with at least one secondary metal ion selected from cobalt ions and manganese ions, immersing the ionically crosslinked scaffold in the dual-metal ion solution to incorporate the metal ions within the scaffold matrix, and drying the scaffold to obtain the dual-metal functionalized three-dimensional chitosan-based scaffold exhibiting structural stability, controlled biodegradation, antibiofilm activity, cytocompatibility, and hemocompatibility.
Disclaimer: Curated by HT Syndication.
