MUMBAI, India, Sept. 28 -- Intellectual Property India has published a patent application (202641112493 A) filed by Andhra University on September 18, 2026, for A Method For Identification And Characterization Of Degradation Impurities Of Sebetralstat.
Inventors include Vijaya Bhaskara Rao Madavamahanti; B. B. V. Sailaja; and Suman Pallapati.
The application for the patent was published on September 25, 2026, under issue no. 39/2026.
Abstract: The present disclosure proposes a method for detection, separation, and structural characterization of degradation impurities of Sebetralstat using chromatographic and mass spectrometric techniques. The method employs reverse-phase high-performance liquid chromatography (RP-HPLC) coupled with liquid chromatography–tandem mass spectrometry (LC-MS/MS) for identifying and characterizing degradation impurities formed during stress degradation of Sebetralstat. The method enables rapid separation and detection of Sebetralstat and its degradation impurities using a stability-indicating RP-HPLC system with optimized chromatographic conditions. The method facilitates accurate structural characterization of degradation impurities through the coupling of chromatographic separation with LC-MS/MS based mass spectral and fragmentation analysis. The method evaluates the stability of Sebetralstat under multiple forced degradation conditions, including acidic, alkaline, oxidative, thermal, photolytic, reductive, and hydrolytic environments.
Disclaimer: Curated by HT Syndication.
