MUMBAI, India, Sept. 28 -- Intellectual Property India has published a patent application (202621095941 A) filed by Dr. Ritika Umeshchandra Gajre; Ms. Prajakta Kulkarni; Ms. Aasiya Khan; Ms. Nidhi Patel; and Dr. Jaswandi Mehetre on August 07, 2026, for A High-Performance Thin Layer Chromatographic (hptlc) Method For Quantitative Estimation Of Pramiracetam.
Inventors include Dr. Ritika Umeshchandra Gajre; Ms. Prajakta Kulkarni; Ms. Aasiya Khan; Ms. Nidhi Patel; and Dr. Jaswandi Mehetre.
The application for the patent was published on September 25, 2026, under issue no. 39/2026.
Abstract: The present invention relates to a validated High-Performance Thin Layer Chromatographic (HPTLC) method for the quantitative estimation of Pramiracetam in bulk drug and pharmaceutical dosage forms. Chromatographic separation is achieved on silica gel 60 F254 precoated HPTLC plates using a mobile phase comprising methanol, toluene and triethylamine in a ratio of 8.0:1.8:0.2 (v/v/v). The chromatographic chamber is saturated for 25 minutes and densitometric scanning is performed at 263 nm. Under the optimized chromatographic conditions, Pramiracetam exhibits a compact and symmetrical chromatographic peak with an Rf value of approximately 0.52 ± 0.02. The method is linear over the concentration range of 200–3200 ng/band with excellent precision, accuracy, specificity, robustness and sensitivity. The method provides a rapid, economical and reproducible procedure suitable for routine quality control, assay determination, validation studies and pharmaceutical quality assurance in accordance with ICH guidelines.
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