MUMBAI, India, Aug. 17 -- Intellectual Property India has published a patent application (202641095931 A) filed by Jyothi Muddagoni on August 07, 2026, for A Green Stability-Indicating Rp-Hplc Method For Simultaneous Estimation Of Diacerein And Methylsulfonylmethane In Pharmaceutical Formulations.
Inventors include Jyothi Muddagoni; Mrs. Saraswathi Mannuri; Dr. Nagaraju Bandaru; Dr. Madhukar Akkala; Mr. Thulasee Nadh Reddy; Dr. Ch. Naveen Kumar; Mrs. Sushma Desai; and Mrs. Vogoti Jhansi Laxmi.
The application for the patent was published on August 14, 2026, under issue no. 33/2026.
Abstract: The present invention relates to a green stability-indicating reverse-phase high-performance liquid chromatographic (RP-HPLC) method for the simultaneous estimation of Diacerein and Methylsulfonylmethane (MSM) in pharmaceutical formulations. Conventional RP-HPLC methods for the analysis of these active pharmaceutical ingredients frequently utilize large volumes of hazardous organic solvents, require extended chromatographic run times, and generate considerable chemical waste, thereby limiting their environmental sustainability and cost-effectiveness. The present invention addresses these limitations by providing an eco-friendly analytical method that employs optimized chromatographic conditions with reduced organic solvent consumption while maintaining excellent analytical performance. The developed method enables rapid, accurate, precise, and selective separation of Diacerein and MSM from formulation excipients, process-related impurities, and degradation products generated under forced degradation conditions, thereby demonstrating its stability-indicating capability. The method is validated in accordance with the International Council for Harmonisation (ICH) Q2(R2) guidelines for specificity, linearity, accuracy, precision, robustness, sensitivity, limit of detection, and limit of quantification. In addition, the method is designed following the principles of Green Analytical Chemistry (GAC) by minimizing hazardous solvent usage, reducing analytical waste, and improving operational efficiency without compromising chromatographic resolution or reproducibility. The invention is suitable for routine pharmaceutical quality control, assay determination, dissolution testing, stability studies, process validation, and regulatory compliance. Owing to its rapid analysis, environmental sustainability, analytical robustness, and industrial applicability, the proposed green stability-indicating RP-HPLC method provides a technically superior and economically viable alternative to conventional chromatographic methods for the simultaneous estimation of Diacerein and Methylsulfonylmethane in pharmaceutical dosage forms.
Disclaimer: Curated by HT Syndication.
