MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202541124405 A) filed by Saveetha Institute Of Medical And Technical Sciences, Chennai, Tamil Nadu, on Dec. 10, 2025, for 'zro2 based nanoparticles for improved ct imaging of head and brain.'
Inventor(s) include Dr. Ramidi Yeshwanth Reddy; Dr Vijayalakshmi; Dr Muthiah; and Dr Deepak Nallaswamy Veeraiyan.
The application for the patent was published on Feb. 13, under issue no. 07/2026.
According to the abstract released by the Intellectual Property India: "The invention relates to zirconium oxide (ZrO2)-based nanoparticles engineered as nextgeneration contrast agents for computed tomography (CT) of the head and brain. Existing iodinated agents are restricted by short circulation times, moderate X-ray attenuation, and risks of nephrotoxicity. The disclosed nanoparticles comprise ZrOi cores sized 10-I00 nm, surface-modified with polyethylene glycol (PEG) or equivalent coatings to ensure colloidal stability, extended vascular residence, and reduced immune recognition. In certain embodiments, targeting ligands such as peptides or antibodies are conjugated to enable selective accumulation in brain tumors, ischemic regions, or sites of blood-brain barrier disruption. Compared with iodine-based agents, these naiioparlicles provide higher attenuation per unit mass, allowing effective imaging at lower doses and minimizing renal burden. Preclinical findings demonstrate enhanced contrast-to-noise ratios, longer imaging windows, and improved delineation of brain pathology. The invention thus offers a safe, efficient, and versatile CT contrast platform, with potential for multimodal applications and clinical translation in neuroimaging."
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