MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202541124415 A) filed by Saveetha Institute Of Medical And Technical Sciences, Chennai, Tamil Nadu, on Dec. 10, 2025, for 'wound healing gel: a rutin-incorporated chitosn nanocomposite product.'
Inventor(s) include Rajeshkumar Shanmugam; Renu Vajjiravelu; Santhoshkumar Jayakodi; and Deepak Nallaswamy Veeraiyan.
The application for the patent was published on Feb. 13, under issue no. 07/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to the preparation of a wound healing gel using Rutin-incorporated Chitosan nanocomposites GMCs) with potent antimicrobial, anti-inflammatory, and membranedisruptive activities. Nanoparticles, due to their ultrafme size (1-100 nm). and unique physicochemical properties, have gained significant biomedical relevance, particularly in drug delivery and regenerative medicine. In this study, Rutin, a naturally occurring flavonoid with strong antioxidant, anti-inflammatory, and vasoprotective properties, was incorporated into Chitosan, a biodegradable polysaccharide known for its wound healing, antimicrobial, and biocompatible nature, to develop an advanced nanocomposite formulation. The antimicrobial activity in opposition to -the tested pathogens. At a dose of 100 pL, the formulation displayed highest antibacterial efficacy opposed to C. albicans (12 mm), S. aureus (32 mm), ancT S. mutans (22 mm), but no inhibition for E. faecalis. Membrane stabilization assays demonstrated significant anti-inflammatory potential, with inhibition increasing from ~50% at 10 pg/mL to over 80% at 50 pg/mL, comparable to the standard drug. Protein leakage studies indicated that the NCs caused substantial membrane damage, leading to protein efflux, with Pseudomonas sp. and S', aureus exhibiting the highest leakage. Cytoplasmic leakage analysis further confirmed bacterial membrane disruption, with maximum leakage observed at higher concentrations, again most pronounced in Pseudomonas sp. and S. aureus. The combined antimicrobial, membranestabilizing, and membrane-disruptive activities suggest that Rutin-incorporated Chitosan NCs can effectively prevent bacterial infection while promoting wound healing. The developed gel formulation provides a moist healing environment, enhances collagen synthesis, reduces inflammation, and offers broad-spectrum antimicrobial protection, making it a promising candidate for treating chronic wounds, burns, ulcers, and surgical injuries. This invention integrates natural bioactive compounds with nanotechnology to create a multifunctional wound healing platform with high therapeutic potential."
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