MUMBAI, India, June 26 -- Intellectual Property India has published a patent application (202521053326 A) filed by Dr. Vishwanath Vithal Bhosale; and Dr. Meghnad Ganesh Joshi on June 02, 2025, for "tissue-Engineered Biodegradable Polymer-Collagen Hybrid Graft For Anterior Cruciate Ligament Repair'.
Inventors include Dr. Meghnad Ganesh Joshi; Mr. Omkar Rajendra Sonkawade; and Miss. Mrunal Narendra Damle.
The application for the patent was published on June 19, 2026, under issue no. 25/2026.
Abstract: Abstract: Ligaments are essential fibrous connective tissues that provide joint stability by connecting bones within the musculoskeletal system. In the knee, the major ligaments—anterior cruciate (ACL), posterior cruciate (PCL), medial collateral (MCL), and lateral collateral (LCL)—play distinct roles in resisting abnormal motion. The ACL and PCL are intra-articular and cross within the joint capsule, with each comprising two functionally distinct bundles that respond differently during knee flexion and extension. Ligament structure primarily consists of aligned Type I collagen fibers interspersed with fibroblasts, contributing to their mechanical strength. Variations in collagen composition and fiber organization influence ligament-specific biomechanical properties. Ligament-to-bone attachment occurs through direct or indirect insertions, involving gradual transitions in tissue types. Injuries to ligaments, especially the ACL, are common and range from mild sprains to complete tears, with diagnosis relying on imaging and physical tests. ACL reconstruction is a critical surgical intervention aimed at restoring knee stability and function following complete ligament rupture. Treatment options include autografts, allografts, or xenografts, with success depending on graft type, tunnel positioning, initial tension, and healing response. Understanding ligament anatomy, composition, biomechanics, and reconstruction strategies is crucial for improving surgical outcomes and advancing tissue-engineered solutions. The present invention relates to a biodegradable polymer-enhanced collagen graft designed for anterior cruciate ligament (ACL) reconstruction. The graft comprises aligned Type I collagen fibers integrated with a biocompatible, biodegradable polymer matrix to improve mechanical strength, promote fibroblast infiltration, and enhance in vivo graft integration. This composite structure mimics native ligament architecture, facilitates early vascularization, and supports gradual load-bearing during healing. The invention offers an alternative to conventional autografts, allografts, and xenografts, aiming to reduce donor site morbidity, immune response, and failure rates associated with traditional methods. The biodegradable polymer component degrades in a controlled manner, synchronized with tissue remodeling, providing a scaffold for endogenous ligament regeneration.
Disclaimer: Curated by HT Syndication.
