MUMBAI, India, Sept. 5 -- Intellectual Property India has published a patent application (202527045155 A) filed by Alphabeta AB, Djursholm, Sweden, on May 9, for 'the bri2 brichos domain for delivery of proteins into cns neurons.'
Inventor(s) include Johansson Jan.
The application for the patent was published on Sept. 5, under issue no. 36/2025.
According to the abstract released by the Intellectual Property India: "An isolated protein comprising (i) a first protein moiety selected from the group of proteins comprising an amino acid sequence having at least 70% identity to residues 113 231 of 5 Bri2 from human (SEQ ID NO: 2); and proteins comprising an amino acid sequence having at least 70% identity to any one of the BRICHOS domains of Bri2 from human (SEQ ID NO: 5) chimpanzee (SEQ ID NO: 6) bovine (SEQ ID NO: 7) pig (SEQ ID NO: 8) mouse (SEQ ID NO: 9) and rat (SEQ ID NO: 10); and10 (ii) a second protein or polypeptide moiety preferably containing at least 50 amino acid residues wherein the second protein or polypeptide moiety is selected from the group consisting of protein drugs polypeptide drugs protein tags fluorescent proteins antibodies enzymes and/or neurotrophic factors;15 wherein said isolated protein is not comprising an amino acid sequence having at least 70% identity to residues 1 89 of Bri2 from human (SEQ ID NO: 3); and wherein said isolated protein is not comprising an amino acid sequence having at least 70% identity to human ABri23 (SEQ ID NO: 4);20 for use as a medicament."
The patent application was internationally filed on Oct. 11, 2023, under International application No.PCT/EP2023/078258.
Disclaimer: Curated by HT Syndication.
