MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202641008052 A) filed by Dr. R. Sireesha; Dr. K. Manikandan; Dr. K. Anand Babu; Mr. R. Harish; Mr. Sudalaimani; Dr Chemalatha; Ms. Soundarya Kasi K; Mr. Likith Kumar; Ms. Atchaya M; and Dr. N Priyanka, Tiruttani, Tamil Nadu, on Jan. 27, for 'targeting foam cell formation in atherosclerosis using a novel polyherbal formulation: analytical and biological insights.'

Inventor(s) include Dr. R. Sireesha; Dr. K. Manikandan; Dr. K. Anand Babu; Mr. R. Harish; Mr. Sudalaimani; Dr Chemalatha; Ms. Soundarya Kasi K; Mr. Likith Kumar; Ms. Atchaya M; and Dr. N Priyanka.

The application for the patent was published on Feb. 13, under issue no. 07/2026.

According to the abstract released by the Intellectual Property India: "The present invention relates to a multiherbal formulation comprising Acacia catechu, Allium sativum, Commiphora mukul, Garcinia cambogia, Helianthus annus, Linum usitatissimum, Piper nigrum, Rubia cordifolia, Terminalia arjuna and Vitis vinifera in powdered form, blended in equal proportions to obtain a churna. The formulation is prepared by shade drying, pulverization and uniform mixing of individual plant materials. Comprehensive standardization is carried out using pharmacognostical, physicochemical, microbiological, spectroscopic and chromatographic parameters. The formulation is characterized by the simultaneous presence and quantification of caffeine, vanillin, trans-ferulic acid, resveratrol, quercetin and kaempferol. In vitro evaluation demonstrates cell viability in THP-1 cell lines and reduced lipid uptake in oxidized LDL-treated THP-1 derived macrophages in a foam cell formation assay. The highest acceptable desirability of 0.979 is achieved in CCD model making it significant. In vitro studies - MTT assay in THP-1 cells followed by foam cell formation assay were selected. MTT assay shows significant cell viability with IC50 values 12 0.01 microgram/ml. The extract reduced the uptake of ox- LDL in foam cell formation assay. The observed findings would suggest that the formulation has reducing effects of macrophage lipid absorption, showing anti-atherosclerotic activity."

Disclaimer: Curated by HT Syndication.