MUMBAI, India, April 10 -- Intellectual Property India has published a patent application (202421075240 A) filed by Tata Consultancy Services Limited, Maharashtra, on Oct. 4, 2024, for 'systems and methods for generating repurposing drug candidates for target diseases.'
Inventor(s) include Ramamurthi, Narayanan; Das, Shyam Sundar; and Ranjan, Pritish.
The application for the patent was published on April 10, under issue no. 15/2026.
According to the abstract released by the Intellectual Property India: "Development of a new drug molecule on average requires an expenditure of US$2-3 billion and a duration of at least 13-15 years. Subsequently, repurposing the existing drugs outside the scope of the original medical indications, has attracted serious consideration. Present disclosure provides a system and method for recommending drug candidates for a target disease by generating drug-refined Medical Subject Headings (MeSH) terms frequency matrix using MeSH terms assigned to Pubmed articles. Further, topic modelling is performed on the drug-refined MeSH terms frequency matrix to generate drug-topic conditional probabilities, and drug-drug distance is computed using Kullback-Leibler divergence. The drugs are then clustered and unknown drugs of a target disease are shortlisted from a cluster with known drugs based on predicted targets and indications of unknown and known drugs. A subset of shortlisted unknown drugs is recommended as a new candidate for target disease based on supporting literature evidence."
Disclaimer: Curated by HT Syndication.
