MUMBAI, India, May 1 -- Intellectual Property India has published a patent application (202641049678 A) filed by Anurag University, Hyderabad, Telangana, on April 18, for 'system for time-controlled release of carvedilol based on circadian rhythm for hypertension management.'
Inventor(s) include Dr. Angilicam Avinash; Ms. Bolledla Nirosha; Ms. P. Ramya Deepthi; and Ms. Josyula Purnanka.
The application for the patent was published on May 1, under issue no. 18/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a system (100) for chronomodulated delivery of carvedilol, comprising a press-coated tablet (101) configured for time-controlled drug release. The tablet (101) includes an inner core (102) containing carvedilol and immediate release excipients, and an outer coating layer (103) composed of rate-controlling polymers. The outer coating layer (103) is associated with a lag-time control mechanism (104) configured to provide a delay of about 4 to 6 hours after administration. Upon completion of the lag time, a burst release mechanism (105) associated with the inner core (102) enables rapid release of the drug. The system (100) is designed for bedtime administration, ensuring drug release during early morning hours corresponding to peak blood pressure levels. The proposed system improves therapeutic efficacy, reduces dosing frequency, and provides a simple and cost-effective approach for managing circadian hypertension."
Disclaimer: Curated by HT Syndication.
