MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202541124406 A) filed by Saveetha Institute Of Medical And Technical Sciences, Chennai, Tamil Nadu, on Dec. 10, 2025, for 'synthesis of iron oxide nanoparticles for mri use in brain lesions.'
Inventor(s) include Dr. Snehaa Lakshmi; Dr. P Vijayalakshmi; Dr. Arundhathy; and Deepak Nallaswamy Veeraiyan.
The application for the patent was published on Feb. 13, under issue no. 07/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a novel and scalable method for synthesizing iron oxide nanoparticles (IONPs) specifically tailored for enhancing magnetic resonance imaging (MRI) contrast in brain lesions. These nanoparticles are engineered with precise control over their size, surface properties, and superparamagnetic behavior, optimizing them for high-resolution imaging of soft tissue abnormalities, particularly in the brain. The method includes the preparation of a stable aqueous solution of iron precursors, followed by the addition of a reducing agent under controlled temperature and pH conditions. This results in the formation of iron oxide nanoparticles with uniform size distribution ranging from 5 to 50 nm. The nanoparticles are further surface-functionalized with biocompatible molecules, such as polyethylene glycol (PEG) or amine groups, to enhance stability, prolong circulation time, and enable targeted delivery to brain lesions. These iron oxide nanoparticles offer significant improvements in MRI contrast, facilitating more accurate detection and diagnosis of brain tumors, stroke, and other neurological disorders, making them a promising alternative to traditional contrast agents."
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