MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202611049353 A) filed by Dr. Akhlesh Kumari; Dr. Sushil Kumar; Mr. Jatin Kishore Sharma; Mr. Sagar Varshney; and Ms. Amisha Varshney, Moradabad, Uttar Pradesh, on April 17, for 'synthesis of 3-(4-(dimethyl amino) phenyl)-1-(4-((3-(m-tolyloxy) propyl) amino) phenyl) prop-2-en-1-one.'
Inventor(s) include Dr. Akhlesh Kumari; Dr. Sushil Kumar; Mr. Jatin Kishore Sharma; Mr. Sagar Varshney; and Ms. Amisha Varshney.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a novel chalcone compound, 3-(4-(dimethylamino)phenyl)-1-(4-((3-(m-tolyloxy)propyl)amino)phenyl)prop-2-en-1-one (compound 7C), and a three-step process for its synthesis as a broad-spectrum antimicrobial agent. Initially, m-cresol reacts with 1-bromo-3-chloropropane in acetonitrile with potassium carbonate to form 1-(3-chloropropoxy)-3-methylbenzene. This intermediate is then coupled with 4-aminoacetophenone to yield a secondary amine, followed by Claisen-Schmidt condensation with 4-(dimethylamino)benzaldehyde in ethanol and potassium hydroxide to produce compound 7C with 43 percent yield and melting point of 193 degrees Celsius. Structural confirmation is achieved by FTIR and H NMR. In silico studies show strong binding to E. coli DNA gyrase and C. albicans lanosterol alpha-demethylase, with favorable ADMET properties. In vitro studies confirm activity against S. aureus, E. coli, C. albicans, and C. mycoderma."
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