MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202611048961 A) filed by Dr. Akhlesh Kumari; Dr. Sushil Kumar; Mr. Jatin Kishore Sharma; Mr. Sagar Varshney; and Ms. Amisha Varshney, Moradabad, Uttar Pradesh, on April 17, for 'synthesis of 3-(4-(dimethyl amino) phenyl)-1-(4-((3-(m-tolyloxy) propyl) amino) phenyl) prop-2-en-1-one.'
Inventor(s) include Dr. Akhlesh Kumari; Dr. Sushil Kumar; Mr. Jatin Kishore Sharma; Mr. Sagar Varshney; and Ms. Amisha Varshney.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to the synthesis and antimicrobial evaluation of a novel chalcone compound, 3-(4-(dimethylamino)phenyl)-1-(4-((3-(m-tolyloxy)propyl)amino)phenyl)prop-2-en-1-one (compound 7C). The compound was synthesized via a three-step process involving Williamson ether synthesis, nucleophilic substitution, and Claisen-Schmidt condensation. Structural characterization was confirmed by FT-IR and H NMR spectroscopy. Molecular docking studies showed strong binding interactions with E. coli DNA gyrase and C. albicans lanosterol alpha-demethylase, indicating potential antimicrobial mechanisms. In-silico ADMET analysis suggested favorable drug-like properties. In-vitro studies demonstrated significant activity against S. aureus, E. coli, C. albicans, and C. mycoderma, with MIC values ranging from 8 to 32 micrograms per mL. The compound shows promise as a broad-spectrum antimicrobial agent."
Disclaimer: Curated by HT Syndication.
