MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202541126685 A) filed by Dhivyadharshini V; Jai Shree S; Menaka R; Sneha Sree V; and G. S. Murugesan, Coimbatore, Tamil Nadu, on Dec. 15, 2025, for 'synergistic anti-urolithiatic potential of achyranthes aspera and tribulus terrestris: a novel polyherbal approach.'
Inventor(s) include Dhivyadharshini V; Jai Shree S; Menaka R; Sneha Sree V; and G. S. Murugesan.
The application for the patent was published on Feb. 13, under issue no. 07/2026.
According to the abstract released by the Intellectual Property India: "Urolithiasis, commonly known as kidney stone disease, is a major urinary disorder predominantly caused by the formation of calcium oxalate crystals. Although numerous medicinal plants are traditionally used in its treatment, the combined effects of such herbs remain insufficiently explored. In India, Achyranthes aspera and Tribulus terrestris are widely utilized due to their proven safety and therapeutic benefits in managing kidney stones. A. aspera is considered a promising source for developing novel anti-urolithiatic agents because of its protective properties and ability to reduce stone recurrence. Similarly, T. terrestris has been reported to inhibit calcium oxalate crystallization, prevent crystal adhesion to renal epithelial cells, and aid in both the prevention and treatment of urolithiasis. The present study evaluates the in vitro effects of extracts of A. aspera and T terrestris on calcium oxalate crystallization. The polyherbal fom1ulation contains key phytochemicals such as saponins, flavonoids, alkaloids, and phenolics, which enhance diuresis, reduce crystal formation, and improve antioxidant activity. In crystal-inhibition assays, the combined extract demonstrated superior activity compared to individual extracts, showing significant reduction in calcium oxalate crystal formation and deposition. These findings suggest that the synergistic combination of A. aspera and T terrestris offers a safe, effective, and promising polyherbal approach for the prevention and management of urolithiasis. KEYWORDS: Achyranthes aspera, Tribulus terrestris, Urolithiasis and in vitro."
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