MUMBAI, India, Feb. 6 -- Intellectual Property India has published a patent application (202541123424 A) filed by Saveetha Institute Of Medical And Technical Sciences, Chennai, Tamil Nadu, on Dec. 8, 2025, for 'silver nanofilm using senna auriculata and symplocos racemosa formulation against wound pathogens.'
Inventor(s) include Dhanyaa Muthukumar; Rajeshkumar Shanmugam; and Deepak Nallaswamy Veeraiyan.
The application for the patent was published on Feb. 6, under issue no. 06/2026.
According to the abstract released by the Intellectual Property India: "To synthesise silver nanoparticles (AgNPs) usmg Senna auriculata and Symplocos racemosa extracts and evaluate their antimicrobial and antibiofilm activities against wound-associated bacterial pathogens. In this study, S auriculata and S racemosa were selected as plant sources for the eco-ftiendly, green synthesis of AgNPs, leveraging their known ethnopharmacological properties. Wound infections are often caused by antibiotic-resistant pathogens such as Pseudomonas sp., Actinobacter sp., Enterococcus faecalis, Escherichia coli, and Staphylococcus aureus, leading to delayed healing and increased morbidity. Silver nanoparticles have emerged as effective antimicrobial agents due to their broad-spectrum activity and ability to disrupt biofilms. Green synthesis using medicinal plants offers a cost-effective route to nanoparticle production, combining phytochemicals with nanotechnology for enhanced therapeutic outcomes. Using an agar well diffusion assay, the AgNPs film was tested against wound pathogens, and the inhibition zones were measured to determine antibacterial efficacy. For Time-Kill Kinetics Assay, the bactericidal effect of AgNPs was analysed over 5 hours using optical density and CFU counts to assess the time- and dose-dependent killing pattern at varying concentrations. For Antibiofilm Assay, Mature biofilms of each pathogen were treated with AgNPs film was quantified using ELISA. AgNPs showed excellent antimicrobial activity, with the largest zone of inhibition against Actinobacter sp. followed by Pseudomonas sp. and S mmius. The time-kill assay revealed that the highest concentration of AgNPs nanofilm significantly reduced viable bacterial counts within 3-4 hours, particularly in E. coli and S. aureus. Antibiofilm activity was also dose-dependent, with Actinobacter sp. biofilms exhibiting the highest sensitivity, followed by S aureus and Pseudomonas sp. The green-synthesised AgNPs ftom S auriculata and S. racemosa demonstrated potent antimicrobial and antibiofilm effects against key wound pathogens. Their incorporation into polymeric nanofilms incorporated in dressing enhances sustained antimicrobial action, supporting their potential use in advanced wound dressings."
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