MUMBAI, India, Feb. 27 -- Intellectual Property India has published a patent application (202531008526 A) filed by Indian Institute Of Technology, Kharagpur, West Bengal, on Feb. 1, 2025, for 'redox-neutral construction of c2-indolyl quaternary/tertiary centers through reverse allylation: access to tryptamine-based alkaloids.'
Inventor(s) include Dr. Modhu Sudan Maji; and Minakshi Ghosh.
The application for the patent was published on Feb. 27, under issue no. 09/2026.
According to the abstract released by the Intellectual Property India: "Redox-Neutral Construction of C2-Indolyl Quaternary/Tertiary Centers through Reverse Allylation: Access to Tryptamine-Based Alkaloids Aromatic C3-alkyl C2-allylated indole derivatives are provided by involving a broad range of structurally and electronically different 3-alkenyl-indoles and allylboronic acids and through an unprecedented reverse allylation strategy to directly access the alkaloid core structure possessing a C2-indolyl tertiary or quaternary center and a functionalizable alkyl chain at the C3 position. A broad substrate scope involving a range of allyl alcohols with electron-withdrawing or electron-donating 3-alkenyl indoles have been tested. The product and the invented methodology of the present invention exhibits wide functional group tolerance and is scalable. Seven tryptamine-based alkaloids, prenylated version of psychedelic drug N,N-DMT, and two dimeric indole alkaloids ()-fluevirine E, ()-mucronatin B have been also synthesized by utilizing the process of the present invention."
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