Intellectual Property India Publishes Patent Application for 'Quantum-Biological Coupling Pattern (QBCP): A Predictive Framework Correlating Electronic Reactivity with Biological Affinity in Sulfonyl-Imidazole Derivatives' Filed by Chennai Institute Of Technology

MUMBAI, India, April 17 -- Intellectual Property India has published a patent application (202641042242 A) filed by Chennai Institute Of Technology, Chennai, Tamil Nadu, on April 2, for 'quantum-biological coupling pattern (qbcp): a predictive framework correlating electronic reactivity with biological affinity in sulfonyl-imidazole derivatives.'

Inventor(s) include Dr. M. Vennila; Dr. P. Elaiyaraja; and Dr. Raja Mohan O S.

The application for the patent was published on April 17, under issue no. 16/2026.

According to the abstract released by the Intellectual Property India: "The current invention presents an innovative quantum-biological framework for forecasting, designing, and enhancing the structural, electronic, thermodynamic, and biological characteristics of sulfonyl-imidazole derivatives, specifically para-toluene sulfonyl imidazole (PTSI) and methyl sulfonyl imidazole (MSI). Utilizing Density Functional Theory (DFT/B3LYP/6-311++G(d,p)), the invention integrates quantum-level electronic analysis with molecular docking and pharmacokinetic modeling, establishing a unified computational-biological approach for multifunctional molecular design. Through a set of newly defined theoretical models-namely, the Quantum-Biological Coupling Pattern (QBCP), Substitution-Controlled Topological Reactivity (SCTR), Delocalization-Rigidity Principle (DRP), and Structure-Property-Function Map (SPFM)-the invention provides predictive relationships between electronic delocalization, topological electron density, and biological recognition. The framework demonstrates that aromatic substitution."

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