MUMBAI, India, Jan. 9 -- Intellectual Property India has published a patent application (202541113646 A) filed by Psg Institute Of Medical Sciences & Research; and Psg College Of Arts & Science, Coimbatore, Tamil Nadu, on Nov. 19, 2025, for 'production of guaiacol based multi-functional glycidyl methacrylate hybrid dental composites.'
Inventor(s) include Srinivasan Harinei; Khaja Najimudeen Mohamed Mydeen; Appasamy Subasri; Dr. Tadury Madhukar Subbarao; Dr. Ellapan Satheeshkumar; and Dr. Muthukaruppan Alagar.
The application for the patent was published on Jan. 9, under issue no. 02/2026.
According to the abstract released by the Intellectual Property India: "The present invention deals with the production and characterization of bio-based non-estrogenic dental restorative hybrid composites using modified 10 guaiacol based multi-functional glycidylmethacrylate (TG-GMA) with biocompatible fillers. The molecular mass (531.37 g/mol) of functionally modified guaiacol (TG) was ascertained from HRMS. The curing ofTG-GMA i; achieved by visible-light irradiation for 75 seconds in the absence of TEGDMA diluent. The curing time of the hybrid matrix comprising 50 wt % of TG-GMA + 50 wt % of 15 TEGDMA in the presence of 5 wt% and JOwt% photo-initiators are found to be 74 and 69 seconds respectively. The curing time of the hybrid matrix comprising of 50 wt % of TG-GMA + 50 wt % of TEGDMA in the presence of 0.5 WI% and I wt% photo-initiators along with fillers are found in the range between 52 anj 68 seconds. The value of water contact angle of TG-GMA is 126 and that of reinforced TG- 20 GMA composites are ranged between 138 and 141. The TG-GMA/TEGDMA hybrid composites exhibit the values of water absorption below 2.5 wt% and solubility less than 3 wt% after immersion in solution having pH of 6 for 7 days at 35 C. The viscosity ofTG-GMA varies within 2% variation over a storage period of 90 days at ambient temperature in light-protected packaging. The compressive 25 strength of cured TG-GMA is 60 MPa and that of TG-GMA reinforced with four different fillers were found in the range between 80 and 95 MPa: The cyto-toxic behaviour of the TG-GMA showing 90% cell viability when tested in-vitro cytotoxicity- MIT method cell line L929 confirrning suitability for biomedical application. Similarly, J'G-GMA possesses an antimicrobial activity against E. coli 30 and S.aureus, with an inhibition zone diameter greater than 12 mm. The present invention considered as cutting-edge concept in the field of utilization of biomaterial for dental restoration."
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