MUMBAI, India, Jan. 9 -- Intellectual Property India has published a patent application (202541113647 A) filed by Psg Institute Of Medical Sciences & Research; and Psg College Of Arts & Science, Coimbatore, Tamil Nadu, on Nov. 19, 2025, for 'production of chain extended vanillyl alcohol based bis-glycidylmethacrylate dental hybrid composite.'
Inventor(s) include Khaja Najimudeen Mohamed Mydeen; Appasamy Subasri; Srinivasan Harinei; Dr. Tadury Madhukar Subbarao; Dr. Ellapan Satheeshkumar; and Dr. Muthukaruppan Alagar.
The application for the patent was published on Jan. 9, under issue no. 02/2026.
According to the abstract released by the Intellectual Property India: "The bio-based non-estrogenic dental restorative hybrid composites are developed using chain extended vanillyl alcohol based bisglycidylmethacrylate (VA- 10 GMA) with bio-compatible fillers. The molecular mass of chain extended vanillyl alcohol bis-glycidyl ether (VAE) obtained from HRMS was found to be 528.55 g/mol. The cyto-toxic behaviour of the YA-GMA showing 90% cell viability when tested in-vitro cyto-toxicity-MTT method cell line L929 confirming suitability for biomedical application. Similarly, VA-GMA possesses an antimicrobial activity 15 against E. coli and S.aureus, with an inhibition zone diameter greater than I 0 mm. The value of water contact angle of V A-GMA is 128 and that of VA-GMA composites are ranged between 134 and 138. Similarly, the values of percentage of moisture absorption of VA-GMA composites are ranged between 3.5% and 5%. The VA-GMA rEGDMA hybrid composites exhibit the values of water absorption below 20 0.5 wt% and solubility less than 0.1 wt% after immersion in solution having pH of 6.5 for 7 days at 35 C. The viscosity ofYA-GMA varies within 3.5% variation over a storage period of 90 days at ambient temperature in light-protected packaging. It was found that the photo-initiator system required to cure VA-GMA is the ratio of 0.5-1 (wt%). The cured depth of the composite exceeds 3 mm under standard dental 25 curing conditions. The curing of V A-GMA is achieved by visible-light irradiation is II 0 seconds in the absence of TEGDMA diluent. The curing time of the hybrid matrix comprising 50 wt% ofTG-GMA +50 wt% ofTEGDMA in the presence of 5 wt% and I Owt% photo-initiators are found to be 120 and I 00 seconds respectively. The curing time of V A-GMA filled with bio- fillers are found in the range of 75 - 90 30 seconds. The compressive strength of YA-GMA matrix is 58 MPa and that of VAGMA composites are observed between 74 MPa and 88 MPa. The present invention considered as cutting-edge concept in the field of utilization of bio-material for dental restoration."
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