MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202611053054 A) filed by Delhi Technological University, New Delhi, on April 25, for 'process for synthesis of 2-amino-5-oxo-4-aryl-4h,5h-pyrano [3,2-c] chromene-3-carbonitriles and their use as cholinesterase inhibitors.'
Inventor(s) include Yadav, Parul; and Singh, Ram.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a green and sustainable process for the synthesis of 2-amino-5-oxo-4-aryl-4H,5H-pyrano[3,2-c]chromene-3-carbonitriles of formula (I) and their application as cholinesterase inhibitors. The process comprises reacting an aryl aldehyde, malononitrile, and 4-hydroxycoumarin in an aqueous plant extract medium, preferably derived from neem leaves, under mild conditions to obtain the desired compounds. The process eliminates the use of synthetic catalysts and organic solvents, thereby providing an environmentally friendly and cost-effective alternative. The synthesized compounds exhibit inhibitory activity against acetylcholinesterase and butyrylcholinesterase enzymes. The invention further provides pharmaceutical compositions comprising the said compounds. The present invention offers advantages including sustainable synthesis, utilization of biomass-derived reaction media, reduced environmental impact, and compounds with potential application in management of neurodegenerative disorders."
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