Intellectual Property India Publishes Patent Application for 'Preparation Of Fused Azole Derivatives As Novel Diacylglyceride O-Acyltransferase 2 Inhibitors' Filed by Merck Sharp & Dohme Llc

MUMBAI, India, July 5 -- Intellectual Property India has published a patent application (202517058230 A) filed by Merck Sharp & Dohme Llc, Rahway, U.S.A., on June 17, for 'preparation of fused azole derivatives as novel diacylglyceride o-acyltransferase 2 inhibitors.'

Inventor(s) include Lim, Yeon-Hee; Hugelshofer, Cedric L.; Roane, James P.; and Shockley, Samantha E.

The application for the patent was published on July 4, under issue no. 27/2025.

According to the abstract released by the Intellectual Property India: "Provided are compounds of Formula I, Formula Ia and Formula Ib and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are DGAT2 inhibitors. Also provided are methods of making compounds of Formula I, Formula Ia and Formula Ib, pharmaceutical compositions comprising compounds of Formula I, Formula Ia and Formula Ib, and methods of using these compounds to treat hepatic steatosis, nonalcoholic steatohepatitis (NASH), hepatic fibrosis, type-2 diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cognitive decline, dementia, cardiorenal diseases such as chronic kidney diseases and heart failure and related diseases and conditions, comprising administering a compound of Formula I, Ia and Ib and the pharmaceutically acceptable salts, esters, and prodrugs thereof, to a patient in need thereof."

The patent application was internationally filed on Nov. 30, 2023, under International application No.PCT/US2023/081717.

Disclaimer: Curated by HT Syndication.