MUMBAI, India, May 29 -- Intellectual Property India has published a patent application (202611051820 A) filed by Ms. Ritika Saxena; Dr. Mukesh Kumar Singh; and Dr. Hemant Arunrao Sawarkar, Moradabad, Uttar Pradesh, on April 23, for 'preparation and evaluation of diazepam-loaded liposomes for anti-anxiety activity.'
Inventor(s) include Ms. Ritika Saxena; Dr. Mukesh Kumar Singh; and Dr. Hemant Arunrao Sawarkar.
The application for the patent was published on May 29, under issue no. 22/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a diazepam-loaded liposomal pharmaceutical composition for anxiety management and its preparation by thin film hydration. Diazepam is encapsulated in phospholipid vesicles formed from soya lecithin and cholesterol (2:1 molar ratio). The components are dissolved in chloroform-methanol (2:1), evaporated at 40-45 C to form a thin film, hydrated with phosphate buffer (pH 7.4), and sonicated to produce nanosized liposomes. The formulation exhibits particle size of 120-250 nm, polydispersity index below 0.5, zeta potential of -20 to -35 mV, and entrapment efficiency up to 85%. It shows sustained biphasic drug release beyond 12 hours. In vivo studies demonstrate enhanced anti-anxiety effects, increased exploratory behavior, reduced dosing frequency, and improved stability compared to conventional diazepam formulations."
Disclaimer: Curated by HT Syndication.
