MUMBAI, India, April 20 -- Intellectual Property India has published a patent application (202411075958 A) filed by Registrar, Maharshi Dayanand University, Rohtak, Haryana, on Oct. 8, 2024, for 'polymeric nanoparticles of immobilized arginine deiminase for biomedical applications.'
Inventor(s) include Anubhuti Kawatra; and Pooja Gulati.
The application for the patent was published on April 17, under issue no. 16/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to the encapsulation of cross-linked enzyme aggregates of arginine deiminase (ADI-CLEA) in biocompatible polylactide co-glycolide nanoparticles (PLGA NPs). More particularly, the present invention aims to enhance the pharmacokinetics and therapeutic efficiency of ADI for biomedical applications. By adopting this approach, the problem of lower activity retention, cellular permanence, immunogenicity, systemic toxicity, and instability at physiological conditions is resolved; frequency of ADI administration and resistance towards treatment can be reduced. The novel ADI-CLEA-NPs can be used in treating healthcare conditions like cancer, arginase-1 deficiency, and viral disorders with minimum side effects. This invention thus deals with compositions of bacterial ADI/biologically active variants thereof, methods for preparation and their usage in biomedical purposes."
Disclaimer: Curated by HT Syndication.
