MUMBAI, India, Feb. 13 -- Intellectual Property India has published a patent application (202611001293 A) filed by Guru Kashi University, Bathinda, Punjab, on Jan. 6, for 'polyherbal multi-target formulation for colon adenocarcinoma management..'
Inventor(s) include Anupam Sharma; Anil Kumar Sharma; Rajender Kumar; Stuti Mittal; Sachin Chawla; Showkat Hussain Bohro; and Ramandeep Kaur Sidhu.
The application for the patent was published on Feb. 13, under issue no. 07/2026.
According to the abstract released by the Intellectual Property India: "The present invention relates to a polyherbal formulation from twelve bioactive phytochemicals derived from six medicinal plants-Nigella sativa, Murraya koenigii, Azadirachta indica, Syzygium cumini, Silybum marianum, and Trachyspermum ammi. These phytochemicals, including Thymoquinone, Nigellidine, Mahanimbine, Koenimbine, Quercetin, Catechin, Ellagic acid, Gallic acid, Silibinin, Isosilybin A, Thymol, and Carvacrol, were selected using a systems biology approach integrating overlapping-gene identification, pathway enrichment and network pharmacology to identify hub target genes. The formulation targets 104 overlapping COAD-associated genes and regulates key hub genes such as CCND1, BCL2, PIK3R1, CDK2, FLT4, GSK3B, CDK4, BCL2L1, MET, and FGFR1. The combined phytochemicals modulate major cancer-related pathways, including the PI3K-Akt signaling pathway, Cell cycle, p53 signaling, Cellular senescence, and broader Pathways in cancer. By simultaneously influencing multiple oncogenic pathways, the invention offers a synergistic, multi-target therapeutic strategy for the prevention and management of Colon Adenocarcinoma (COAD). The composition can be formulated into various dosage forms suitable for clinical use."
Disclaimer: Curated by HT Syndication.
